UJI IN VITRO AKTIVITAS ANTIAGGREGASI PLATELET EKSTRAK ETANOL BUAH CABAI RAWIT (CAPSICUM FRUTESCENS, L. )DENGAN METODE BORN

Raden Retno Ariani (1)
(1) Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Al-Ghifari
https://doi.org/10.53675/jsfar.v12i2.1416
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Issue
Vol. 12 No. 2 (2024): SABDARIFFARMA
Submitted
2025-02-18
Published
2025-02-25
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Abstract

Buah cabai rawit  dikenal dengan nama latin Capsicum frutescens .L, kaya akan manfaat dan banyak dihasilkan di Indonesia. Hasil penelitian metanalisis terdahulu salah satu manfaat dari buah cabai rawit adalah kemampuannya dalam menurunkan angka kejadian penyakit kardiovaskular. Antiaggregasi platelet merupakan salah satu golongan obat yang umum digunakan untuk mencegah penyakit kardiovaskular pada pasien dengan faktor risiko. Penelitian ini bertujuan untuk mengidentifikasi aktivitas antiaggregasi platelet pada ekstrak etanol buah cabai rawit dalam mencegah kejadian penyakit kardiovaskular serta menentukan konsentrasi hambat 50% (IC50) dari ekstrak tersebut. Metode yang digunakan adalah metode Born, yang menerapkan prinsip turbidimetri dengan menggunakan Plasma Rich Platelet (PRP) manusia dengan pembanding asetosal. Hasil penelitian menunjukkan bahwa ekstrak etanol memiliki aktivitas antiaggregasi platelet secara in vitro dengan IC50 sebesar 5147,92 µg/mL dan asetosal sebesar 517,02 µg/mL. Untuk mencapai konsentrasi hambat yang setara dengan asetosal, ekstrak etanol buah cabai rawit memerlukan konsentrasi yang jauh lebih tinggi.

Authors

Raden Retno Ariani
Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Al-Ghifari
https://orcid.org/0009-0002-3811-7071 (unauthenticated)
Program Studi Farmasi

How to Cite

UJI IN VITRO AKTIVITAS ANTIAGGREGASI PLATELET EKSTRAK ETANOL BUAH CABAI RAWIT (CAPSICUM FRUTESCENS, L. )DENGAN METODE BORN. (2025). Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi, 12(2), 1-6. https://doi.org/10.53675/jsfar.v12i2.1416

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References

BPS. (2021). Bunga Rampai Statistik Percabaian. Jakarta: Badan Pusat Statistik.

PDSKI. (2022). Panduan Prevensi Penyakit Kardiovaskular Aterosklerosis. Jakarta: Perhimpunan Dokter Spesialis Kardiovaskular Indonesia.

RAHMI, Y. (2016, Maret 1). Penentuan Kandungan Kapsaisin pada Berbagai Buah Cabai (capsicum) dengan Metode Kromatografi Cair Kinerja Tinggi (kckt). Retrieved from e-Skripsi Universitas Andalas: http://scholar.unand.ac.id/id/eprint/2603

Richard Ofori-Asenso, R. O.-A. (2021, march 04). Association of Spicy Chilli Food Consumption With Cardiovascular and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies. Angiology, 625 - 632.

Rumbaut RE, T. P. (2010). Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis. San Rafael (CA): Morgan & Claypool Life Sciences.

Sefi Megawati, R. R. (2021, February). Evaluasi Penggunaan Obat Antiplatelet pada Pasien Stroke Iskemik di Instalasi Rawat Inap Rumah Sakit Umum Kabupaten Tangerang ahun 2019. Jurnal Farmagazine, 39-45.

SKI. (2024). Laporan Tematik Survei Kesehatan Indonesia Tahun 2023. Jakarta: KEMENTRIAN KESEHATAN REPUBLIK INDONESIA.

Suryani, R. (2023). Outlook Komoditas Pertanian Subsektor Holtikultura CABAI. Jakarta: Pusat Data Sistem Informasi dan Pertanian Kementerian Pertanian .

Vogel, H. (2002). Drug Discovery and Evaluation Pharmacological Assay , 2nd ed. Berlin: Springer.