PENGEMBANGAN DAN VALIDASI METODA ANALISIS PENENTUAN KADAR TABLET DIETILKARBAMAZINE SITRAT 100 MG DENGAN METODA KROMATOGRAFI CAIR KINERJA TINGGI

Kusdi Hartono (1) , Ginayanti Hadisoebroto (2)
(1) Prodi Farmasi Universitas Al-Ghifari,
(2) Prodi Farmasi Universitas Al-Ghifari
https://doi.org/10.53675/jsfar.v1i1.15
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Issue
Vol. 8 No. 1 (2020): SABDARIFFARMA
Submitted
2020-07-07
Published
2019-11-20
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Abstract

Penetapan  kadar obat dalam  suatu sediaan membutuhkan suatu metoda yang teliti dan akurat serta waktu yang  lebih  singkat. Telah dilakukan  pengembangan metoda analisis penentuan kadar  tablet Dietilkarbamazin Sitrat 100 mg dengan metoda kromatografi cair kinerja tinggi dengan mengoptimasi perbandingan komposisi fase gerak campuran larutan dapar fosfat dan metanol dengan perbandingan (60 : 40), (70 : 30), dan (80 : 20). Hasil optimasi fase gerak menunjukan perbandingan komposisi fase gerak campuran larutan dapar fosfat dan metanol  (80 : 20) yang paling optimal, Selanjutnya dilakukan validasi metoda analisisnya. Hasil validasi  pada penelitian ini menujukkan hasil yang memenuhi persyaratan validasi yaitu relatif standar deviasi (RSD ) pada uji presisi 0,4231 % (syarat  ≤  2,0 %), rata-rata % recovery akurasi 99,48 % (syarat 98,0 % – 102,0 %), Nilai r pada uji Linearitas 0,9994  (syarat  r 0,999), RSD Kesesuaian sistem 0,2283 %, dan  Selektivitas 100,30 % - 100,49 %  (syarat 95,0 % - 105,0 %).

Authors

Kusdi Hartono
Prodi Farmasi Universitas Al-Ghifari
Ginayanti Hadisoebroto
Prodi Farmasi Universitas Al-Ghifari

How to Cite

PENGEMBANGAN DAN VALIDASI METODA ANALISIS PENENTUAN KADAR TABLET DIETILKARBAMAZINE SITRAT 100 MG DENGAN METODA KROMATOGRAFI CAIR KINERJA TINGGI. (2019). Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi, 8(1), 11-21. https://doi.org/10.53675/jsfar.v1i1.15

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References

Departemen Kesehatan RI. 2009. Suplemen II Farmakope Indonesia Edisi IV. Jakarta : Departemen Kesehatan RI. Halaman 1853-1856.

Departemen Kesehatan RI. 2014. Farmakope Indonesia Edisi V. Jakarta : Departemen Kesehatan RI. Halaman 312 - 313.

Ermer J and Miller JH McB., Method validation in Pharmaceutical Analysis., Wiley-VCH, 2005

Harmit., Desember 2004., Petujuk pelaksanaan validasi metode dan cara perhitungannya., Departemen Farmasi FMIPA-UI., Jurnal Majalah Ilmu Kefarmasian, volume I. No. 3.

Masrizal., September 2012- Maret 2013., Penyakit Filariasis., Jurnal Kesehatan Masyarakat. Volume 7. No. 1.

Usman , H., Dan R. Purnomo Setiady Akbar., 2000., Pengantar Statistika. Jakarta., Bumi Aksara

United State Pharmacopeial Convetion., 2013., United State Pharmacopeia 36 NF 31. Volume II. Baltimore : United Book Press, Inc. halaman 3234 – 3235

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